Utilizing solitary-molecule optical and AFM imaging and drive-spectroscopy methods, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our research interests include:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
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Deposition and atomic force microscopy of individual phthalocyanine polymers between nanofabricated electrodes
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Instance (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim in the pore is highlighted in red, and also a 3D rendering in the movement on the DNA rod is displayed.
A lot of linked developments adopted, wherever our team recognized unique transistor variants which include one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled various transistors into small evidence-of-basic principle Digital circuits.
He also discovered time to write down quite a few publications, mail Virtually forty thousand tweets and guide a successful investigation team at Delft University of Know-how. ‘It doesn’t feel like operate’, he suggests. ‘I’m just terribly curious.’
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At this cees dekker time, we also realized that it ought to be doable to implement one semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched individual semiconducting nanotubes throughout metallic electrodes and applied the fundamental silicon substrate like a gate electrode, setting up The essential a few-terminal format of the discipline-impact transistor (Fig.
Illustration (four) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in crimson, as well as a 3D rendering of the movement with the DNA rod is exhibited.
Later on we spoke again briefly simply because Dekker felt that our discussion of his faith promptly turned purely philosophical, Whilst it also concretely assists him in his do the job.
Enable’s to start with look back in the mean time if you chose to shift your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and single-molecule experiments